According to Dalrymple in his medical column at Pajamas Media, advances in our understanding of genetics have provided some clinical benefits but fewer than predicted, mostly because they have been trumped by non-genetic factors.
The Skeptical Doctor
Dedicated to the work of Theodore Dalrymple
Thanks for posting this but the link failed (a couple of spaces in there).
Try http://pjmedia.com/lifestyle/2013/12/25/why-is-it-so-difficult-to-translate-genetic-breakthroughs-into-clinical-benefits/?singlepage=true
Thanks, Alex. I corrected the link.