Probably very, is the answer. But as usual with Dalrymple’s Pajamas Media columns, the most quotable part is the introduction:
Man is a creature that likes to change his mental state, even if it is for the worse. It is the change that he seeks, not the end result; Nirvana for him is a constantly fluctuating or dramatic state of mind. This, for obvious reasons, is particularly so for the bored and dissatisfied. In the prison in which I worked, for example, the prisoners would take any pills that they happened to find in the hope that they would have some — any — effect on their mental state, irrespective of the dangers that might be involved in producing it.